Gestational Trophoblastic Disease

Staging of Gestational Trophoblastic Disease*

STAGE I
Disease confined to uterus
STAGE II
GTN extending outside uterus but limited to genital structures (adnexa, vagina, broad ligament)
STAGE III
GTN extending to lungs with or without known genital tract involvement
STAGE IV
All other metastatic sites

+ Prognostic score*

FIGO Scoring 0 1 2 4
Age <40 >40
Antecedent pregnancy HM Abortion
Interval months from index pregnancy <4 4-6 7-12 >12
Pretreatment hCG (mIU/ml) <103 103-104 104-105 >105
Largest tumor size including uterus  – 3-4cm ≥ 5cm  –
Site of metastases including uterus lung spleen,kidney GIT liver
Number of metastases 1-4 5-8 >8
Previous failed chemotherapy  –  Single drugs >2 drug

*Low risk ≤ 6; High risk ≥ 7 

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